.alpha.-glycosyl derivative of the catecholamine or its salt, an

Details .alpha.-glycosyl derivative of the catecholamine or its salt, an .alpha.-glycosyl derivative of the catecholamine or its salt, an

1994-08-26

1997-08-12

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 99, 435193, 435204, 435205, 536 111, 536 41, 536 179, 514 25, C12P 1944, A61K 3170

Patent

active

056564600

ABSTRACT:
Disclosed is a novel .alpha.-glycosyl derivative of a catecholamine or its salt, said .alpha.-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an .alpha.-glucosyl saccharide and one of catecholamines in order to form an .alpha.-glycosyl derivative of said catecholamines, and recovering the resultant .alpha.-glycosyl derivative. The .alpha.-glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the .alpha.-glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc.

REFERENCES:
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"Denpun-Kagaku-Handbook (Handbook of Starch Science)", p. 190 (1984), published by Asakura Shoten Publisher.
The Journal of Biological Chemistry; vol. 153, Baltimore (1944).
Ishizaki et al.; "Further studies on dopamine and N-acyldopamine during the pupal stage of papilio xuthus (lepidoptera: papiliondae)"; Comp. Biochem. Physiol., vol. 97B, No. 3, pp. 563-567
Kebabian et al; "Dopamine-sensitive adenylate cyclase in caudate nuclus of rat brain, and its similarity to the `Dopamine Receptor`", Proc. Nat. Acad. Sci. USA, vol. 69, No. 8, pp. 2145-2149 (Aug. 1972).
Mueller, D.D. et al.; ".sup.1 H and .sup.13 C NMR of 3-O and 4-O conjugates of dopamine and other catecholamines", Bioconjugate Chem. 4:47-53 (1993).

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