.alpha.-Glycosyl derivative of catecholamine or its salt, and it

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 74, 435205, 435 99, 435193, 435204, 536 111, 536 41, 536 179, C07H 1500, C12N 934, C12P 1944, A61K 3170

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active

056725876

ABSTRACT:
Disclosed is a novel .alpha.-glycosyl derivative of a catecholamine or its salt, said .alpha.-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an .alpha.-glucosyl saccharide and one of catecholamines in order to form an .alpha.-glycosyl derivative of said catecholamines, and recovering the resultant .alpha.-glycosyl derivative. The .alpha.-glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the .alpha.-glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc.

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The Journal of Biological Chemistry; vol. 153, Baltimore (1944).
Ishizaki et al.; "Further studies on dopamine and N-acyldopamine during the pupal stage of papilio xuthus (lepidoptera: papiliondae)"; Comp. Biochem. Physiol., vol. 97B, No. 3, pp. 563-567.
Kebabian et al.; "Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the `Dopamine Receptor`", Proc. Nat. Acad. Sci. USA, vol. 69, No. 8, pp. 2145-2149 (Aug. 1972).
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