.alpha.-Glycosyl derivative of catecholamine or its salt, and it

Details .alpha.-Glycosyl derivative of catecholamine or its salt, and it .alpha.-Glycosyl derivative of catecholamine or its salt, and it

1995-06-07

1997-09-30

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 74, 435205, 435 99, 435193, 435204, 536 111, 536 41, 536 179, C07H 1500, C12N 934, C12P 1944, A61K 3170

Patent

active

056725876

ABSTRACT:
Disclosed is a novel .alpha.-glycosyl derivative of a catecholamine or its salt, said .alpha.-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an .alpha.-glucosyl saccharide and one of catecholamines in order to form an .alpha.-glycosyl derivative of said catecholamines, and recovering the resultant .alpha.-glycosyl derivative. The .alpha.-glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the .alpha.-glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc.

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"Denpun-Kagaku-Handbook (Handbook of Starch Science)", p. 190 (1984), published by Asakura Shoten Publisher.
The Journal of Biological Chemistry; vol. 153, Baltimore (1944).
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Kebabian et al.; "Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the `Dopamine Receptor`", Proc. Nat. Acad. Sci. USA, vol. 69, No. 8, pp. 2145-2149 (Aug. 1972).
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