.alpha.-glycosyl derivative of catecholamine or its salt, and it

Details .alpha.-glycosyl derivative of catecholamine or its salt, and it .alpha.-glycosyl derivative of catecholamine or its salt, and it

1993-05-07

1995-01-10

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 74, 435205, C07H 1500, C12N 934, C12P 1944

Patent

active

053808371

ABSTRACT:
Disclosed is a novel .alpha.-glycosyl derivative of a catecholamine or its salt, said .alpha.-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an .alpha.-glucosyl saccharide and one of catecholamines in order to form an .alpha.-glycosyl derivative of said catecholamines, and recovering the resultant .alpha.-glycosyl derivative. The .alpha.-glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the .alpha.-glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc.

REFERENCES:
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Seikagaku-Jikken Koza, "Metabolism of amino acids, and in vivo amines", Part B, vol. 11, pp. 725-753 (1977) The Japanese Biochemical Society.
"Denpun-Kagaku-Handbook (Handbook of Starch Science)", p. 190 (1984), published by Asakura Shoten Publisher.
The Journal Biological Chemistry; vol. 153, Baltimore (1944).
Ishizaki et al.; "Further studies on dopamine and N-acyldopamine during the pupal stage of papilio xuthus (lepidopera: papiliondae)", pp. 563-567 (1990); Comp. Biochem. Physiol, vol. 97B, No. 3.
Kebabian et al.; "Dopamine-Sensitive Adenylate Cyclase in Caudate Nuclus of Rat Briain, and Its Similarity to the Dopamine Receptor", pp. 2145-2149 (Aug. 1972); Proc. Nat. Acad. Sci. USA, vol. 69, No. 8.

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