.alpha.-glycosyl derivative of catecholamine or its salt, and it

Details .alpha.-glycosyl derivative of catecholamine or its salt, and it .alpha.-glycosyl derivative of catecholamine or its salt, and it

1995-06-07

1998-01-20

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 179, 435 74, A61K 3170, C07H 1520, C12P 1944

Patent

active

057101337

ABSTRACT:
Disclosed is a novel .alpha.-glycosyl derivative of a catecholamine or its salt, said .alpha.-glycosyl derivative being prepared by allowing a saccharide-transferring enzyme together with or without glucoamylase to act on a solution containing an .alpha.-glucosyl saccharide and one of catecholamines in order to form an .alpha.-glycosyl derivative of said catecholamines, and recovering the resultant .alpha.-glycosyl derivative. The .alpha.-glycosyl derivative overcomes conventional drawbacks of catecholamines, and does not substantially exhibit or have a reducing activity and undesirable toxicity, but has a relatively-high stability and exerts the inherent physiological activities of catecholamines in vivo. Thus, the .alpha.-glycosyl derivative is advantageously used as a variety of pharmaceuticals in the form of an injection, tablet, etc.

REFERENCES:
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