Alpha-functionalized derivatives and labeled conjugates of proca

Details Alpha-functionalized derivatives and labeled conjugates of proca Alpha-functionalized derivatives and labeled conjugates of proca

1985-03-18

1987-06-16

Foelak, Morton

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564163, 564156, 562450, 435188, 435 7, C12N 996

Patent

active

046737634

ABSTRACT:
Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the .alpha.-position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are .alpha.-position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.

REFERENCES:
patent: 4235969 (1980-11-01), Singh et al.
patent: 4241177 (1980-12-01), Singh et al.
Mojaverian et al, "Production and Characterization of Specific Antibody for . . . Procainamide", J. Pharmac. Sci., 69(6) 1980, pp. 721-724.

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