Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1984-03-07
1986-04-15
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560 60, 560183, 560184, 560174, 560227, 562586, 556470, C07C 6976, C07C 6973, C07C 6966
Patent
active
045829241
ABSTRACT:
An .alpha.-fluoroalkyl carboxylic acid ester of the general formula ##STR1## wherein A is R.sup.1 R.sup.2 COR.sup.3 -- or R.sup.4 CO--, wherein R.sup.1 and R.sup.2 are independently hydrogen, alkyl, alkoxyl or phenyl, with or without the formation of a common ring therebetween, R.sup.3 is hydrogen or alkyl, R.sup.4 and R are independently alkyl, and R.sub.f is fluoroalkyl. The .alpha.-fluoroalkyl carboxylic acid ester is prepared by reacting a fluoroalkyl silyl ketene acetal of the formula ##STR2## wherein R' is alkyl and R.sub.f and R are the same as defined above, with the corresponding acetal, ketone or acyl halide.
REFERENCES:
Purrington et al., "Prep of Esters Containing an .alpha.-CF.sub.3 Group", in Tetrahedron Letters, vol. 25, No. 13, pp. 1329-1332, 1984.
Nakai et al., "Silyl Ketene Acetal Derived from Methyl .beta.,.beta.,.beta.-Trifluoropropionate: A Versatile Reagent for Synthesis of .alpha.-Trifluoromethyl Carboxylic Esters", from Abstracts of 186th A.C.S. Meeting, D.C. 8/83, Fluo 24, Title and Contributor pages to Tetrahedron Letters, vol. 23, No. 10. pp. 1015, 1017.
Buxton et al., Journal of the Chemical Society, part 1, (1955), pp. 366-374.
Ishikawa Nobuo
Nakai Takeshi
Daikin Kogyo Co. Ltd.
Killos Paul J.
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