.alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivati

Details .alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivati .alpha.-fluoro-.alpha.-1-(1,2,4-triazolyl)-phenylmethyl derivati

1995-06-07

1997-06-10

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514384, 5482622, 5482636, 5482638, 5482642, 5482644, 5482674, 5482676, 5482678, 5482686, A61K 3141, C07D24908

Patent

active

056376057

ABSTRACT:
Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

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Taylor et al "Aromatase Inhibition by 5-Substituted Pyrimidines and Dihydropyrimidines" J. Med Chem (1987) vol. 30 pp. 1359-1365.

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