Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1989-07-26
1991-12-24
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
5142375, 5142378, 5142388, 514255, 514313, 514330, 514331, 514423, 514426, 514428, 514594, 514616, 514620, 544164, 544168, 544382, 544390, 544400, 546224, 546226, 546232, 546244, A61K 3116, A61K 31165, A61K 3117, C07C23700
Patent
active
050753371
ABSTRACT:
Deuterated 2-alkylaminoacetamide compounds are described having the alpha carbon of the alkyl side chain of the compounds substituted by one or two deuterium atoms. These compounds have pharmacokinetic properties which enable treatment of CNS diseases with lower toxic effects. These compounds are also useful in evaluating the metabolic fate of non-deuterated counterpart compounds. Of particular interest are compounds of Formula I: ##STR1## wherein X is deutero or hydrido; wherein R.sup.1 is selected from alkyl and aralkenyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and alkyl; wherein each of R.sup.1, R.sup.2 and R.sup.3 having a substitutable position may be substituted with one or more halo radicals; or a pharmaceutically-acceptable salt thereof.
REFERENCES:
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A. B. Foster et al., Advances in Drug Research, vol. 14, pp. 2-36, Academic Press, London, (1985).
A. G. Goodman et al., Basis of Therapeutics, 7th Edn., p. 15, Mac Millan & Co., New York (1985).
P. L. Dostert et al., Med. Res. Rev., 9, 45-89 (1989).
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Cordi Alex A.
Gorissen Hugo
Janssens de Varebeke Philippe
G. D. Searle & Co.
Keane J. Timothy
Lee Mary C.
Matukaitis Paul D.
Powers Fiona T.
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