Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-11-08
1997-06-03
Conrad, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
5361231, 53612313, 548413, 548526, 549221, 549430, 554103, 554104, 560 16, 560 20, 560 22, 560 24, 560 43, 560 45, 560 55, 560 84, 562 8, 562 9, 562 24, 562426, 562434, 562470, 562471, C07H 100, C13K 1300, C07F 902, C07F 928, C07F 922, C07C22900, C07C 5948
Patent
active
056356080
ABSTRACT:
The invention relates to caged compounds for the study of biological processes, where the caged compound has a photoremoveable .alpha.-carboxy-substituted o-nitrobenzyl group. Covalent attachment of the substituted o-nitrobenzyl to a parent compound yields a caged compound with biological and/or physical properties that are significantly altered from the original properties of the parent compound. Illumination of the caged compounds to cleave the photoremoveable group yields the parent compound with its original properties restored.
REFERENCES:
patent: 4945171 (1990-07-01), Haugland et al.
patent: 5227487 (1993-07-01), Haugland et al.
Krebs, et al., Chem. Ber. (89), 875-83 1956.
Wieboldt, et al. Proc. Natl. Acad. Sci. 91(19) pp. 8752-8756 Sep. 13, 1994.
Walker, et al. J. Biol Chem. 267(4), 2459 1992.
Corrie, J. Chem Soc, Perkin Trans. 1, 2161 (1993).
Walker, et al., Biochem, 32, 1338 (1993).
Wieboldt, et al., Biochem, 33, 1526 (1994).
Corrie, et al., J. Physiol, (London) 465, 1 (1993).
Ramesh, et al., J. Org. Chem. 58, 4599 (1993).
Milburn, et al., Biochem 28, 49 (1989).
Walker, et al., J. Am. Chem. Soc. 110, 7170 (1988).
Wilcox, et al., J. Org. Chem. 55, 1585 (1990).
Wieboldt, et al., PNAS/USA 91(19), 8752 (1994).
Cummings, et al., Tet. Lett. 29, 65 (1988).
Gee Kyle R.
Haugland Richard P.
Conrad Joseph
Helfenstein Allegra J.
Molecular Probes, Inc.
Skaugset Anton E.
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