Alpha carbolines and uses thereof

Details Alpha carbolines and uses thereof Alpha carbolines and uses thereof

2007-02-15

2010-10-12

Solola, Taofiq A (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S292000, C544S126000, C546S087000

Reexamination Certificate

active

07812018

ABSTRACT:
This invention provides alpha-carboline compounds of formula I:wherein R1, R2, R3, R4, R5, and x are as described in the specification. The compounds are useful for treating inflammatory diseases and cancer.

REFERENCES:
patent: WO 2004/054505 (2004-07-01), None
Golovko, T.V., et al., “New Synthesis of Beta-(2-alkoxyindolyl-3) Acrylic Acid Derivatives,”Khimiko-Farmatsevticheskii Zhurnal, Moscow, Russia, vol. 28, No. 5, (1994), pp. 48-50.
Golovko, T.V., et al., “A New Approach to the Synthesis of Functionally-Substituted Pyrido[2, 3-d]indoles”,Mendeleev Communications, Institute of Physics Publishing, Bristol, GB, vol. 6, (1995), pp. 226-227.
Frederiksen, H., et al., “Identification of Metabolites in Urine and Feces from Rats dosed with the Heterocyclic Amine, 2-amino-3-methyl-9H-pyrido[2, 3-b]Indole (MeAalphaC),”Drug Metabolism and Disposition, vol. 32, No. 6, (Jun. 1, 2004), pp. 661-665.
Isakovich, I.P., et al., “Synthesis of Condensed Indole Derivatives Based on 1-(2, 6-dichlorophenyl)-3-[(dimethylamino)methylene]-2-indolinone,”Khimiko-Farmatsevticheskii Zhurnal, vol. 30, No. 9, (1996), pp. 35-39.
International Search Report filed in International Application No. PCT/US2007/003989, which corresponds to U.S. Appl. No. 11/706,760, filed Feb. 15, 2007.

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