.alpha.-branched anilines, toluenes, and analogs thereof as fact

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514416, 514535, 514561, 514568, 514647, 514649, 546334, 546336, 548494, 548504, 560 34, 560 35, 560 55, 562426, 562429, 562430, 562433, 564149, 564162, 564164, 564336, A61K 31215, A61K 31195, A61K 3123, C07C22914, C07C21100, C07C21302

Patent

active

059425440

ABSTRACT:
The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.

REFERENCES:
patent: 5187157 (1993-02-01), Kettner et al.
patent: 5492895 (1996-02-01), Vlasuk et al.
Tidwell et al., Thrombosis Research 1980, 19, 339-349, "Strategies for Anticoagulation with Synthetic Protease Inhibitors. Xa Inhibitors Versus Thrombin Inhibitors".

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