.alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibito

Details .alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibito .alpha.-aryl or heteroaryl-substituted amide ester ACAT inhibito

1995-03-06

1996-03-26

Dees, Jose/ G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514256, 514275, 514357, 544329, 544332, C07D21355

Patent

active

055021980

ABSTRACT:
Pharmaceutically useful compounds having acyl-coenzyme A: cholesterol acyltransferase inhibitory activity having the general formula ##STR1## wherein Ar is di- or trisubstituted aryl or heteroaryl; R.sub.14 and R.sub.15 are each independently aryl, heteroaryl, hydrogen, fluorine, or alkyl, with the proviso that R.sub.14 and R.sub.15 are not both hydrogen, fluorine, or a straight or branched chain alkyl or a combination thereof; and R.sub.16 is a straight or branched hydrocarbon chain having 1 to 20 carbon atoms and is saturated or unsaturated and has 1 to 3 double bonds, the double bonds being adjacent or nonadjacent.

REFERENCES:
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patent: 5079137 (1992-01-01), Taguchi et al.
patent: 5123951 (1992-06-01), See et al.
patent: 5334747 (1994-08-01), Steffen et al.
PCT Search Report, PCT/US 94/12299.
Chemical Abstracts, vol. 112, No. 9, 1990, abstract No. 76532b, Hyun et al.
Chemical Abstracts, vol. 91, No. 91, 1979, abstract No. 20134d, Stopsack et al.
Chemical Abstracts, vol. 55, No. 5, 1961, abstract No. 4425e, Heilmittelwerke Wien GmbH.

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