.alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al

Details .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al

1978-09-08

1980-08-12

Waltz, Thomas A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260558A, 260465E, 424320, 424324, C07C10320, C07C10319, A61K 3116, A61K 31165

Patent

active

042173060

ABSTRACT:
Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.

REFERENCES:
patent: 2884436 (1959-04-01), Janssen et al.
patent: 2894955 (1959-07-01), Aspergren et al.
patent: 3022302 (1962-02-01), Martensson et al.
patent: 3022314 (1962-02-01), Aspergren et al.
patent: 3078275 (1963-02-01), Moffett et al.
patent: 3225091 (1965-12-01), Ainsworth et al.
patent: 3344146 (1967-09-01), Casadio
Stenseth et al., J. Org. Chem. 34 (10), 3007-3010 (1969).
Pala et al., J. Med. Chem. 16 (6), 720-723 (1973).
Casadio et al., J. Med. Chem. 9 (5), 707-714 (1966), 8 (5), 594-598 (1965).
Borovicka et al., CA 52:5335i (1958).
Blicke et al., J. Am. Chem. Soc., 75, 4334-4335 (1953).

Affiliated with

Also associated with

Rating

.alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2182185