.alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al

Details .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al .alpha.-Aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)al

1977-03-11

1978-08-15

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BF, 260295AM, 26029369, 26029376, 26032643, 424244, 42424854, 424263, 424267, 424274, 424324, 544131, 544168, 544163, 544124, A61K 31165, C07C10328

Patent

active

041072057

ABSTRACT:
Novel .alpha.-aryl-.alpha.,.alpha.-bis[.omega.-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentrated sulfuric acid.

REFERENCES:
patent: 2884436 (1959-04-01), Janssen et al.
patent: 2894955 (1959-07-01), Aspergren et al.
patent: 3022314 (1962-02-01), Aspergren et al.
patent: 3078275 (1963-02-01), Moffett et al.
patent: 3225091 (1965-12-01), Ainsworth et al.
patent: 3344146 (1967-09-01), Casadio
Casadio et al., J. Med. Chem. 8 (5), 594-598 (1965).

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