Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-02-08
1976-03-02
Todd, G. Thomas
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602475G, 260268H, 26029362, 26029364, 26029368, 26029371, 26029379, 26029384, 424248, 424250, 424267, C07D21122
Patent
active
039417956
ABSTRACT:
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1##
Wherein R.sup.1 represents cyclohexyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl is selected from halogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, or a lower alkoxy group of from 1 to 4 carbon atoms; R.sup.2 represents hydrogen or hydroxy; R.sup.3 represents hydrogen, or R.sup.2 and R.sup.3 taken together form a second bond between the carbon atoms bearing R.sup.2 and R.sup.3 ; n is an integer of from 1 to 3; Z represents thienyl, naphthyl, phenyl, or substituted phenyl wherein the substituent on the substituted phenyl may be attached at the ortho, meta or para position of the phenyl ring and is selected from halogen, a straight or branched alkyl group of from 1 to 6 carbon atoms, an alkoxy group of from 1 to 6 carbon atoms, a cycloalkyl group of from 3 to 6 carbon atoms, di(lower)alkylamino, or a saturated monocyclic heterocyclic group such as pyrrolidino, piperidino, morpholino, or N-(lower)-alkylpiperazino with the proviso that when R.sup.1 is phenyl, Z is naphthyl or phenyl substituted with a straight or branched alkyl group of 5 or 6 carbon atoms, a lower alkoxy group of 5 or 6 carbon atoms, or a cycloalkyl group of from 3 to 6 carbon atoms. Pharmaceutically acceptable acid addition salts and individual optical and geometric isomers of compounds of the above formula are also included as a part of this invention.
REFERENCES:
patent: 3806526 (1974-04-01), Carr et al.
patent: 3829433 (1974-08-01), Carr et al.
patent: 3839431 (1974-10-01), Sheehan et al.
Carr Albert A.
Kinsolving C. Richard
Hattan L. Ruth
Rauchfuss, Jr. George W.
Retter Eugene O.
Richardson-Merrell Inc.
Todd G. Thomas
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