Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyri

Details Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyri Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyri

1976-06-24

1977-11-01

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260295R, 260296D, 260297R, 424263, C07D21389

Patent

active

040565327

ABSTRACT:
Alpha-aryl-2-pyridineethanol 1-oxides and alpha-pyridinyl-2-pyridineethanol 1-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, ortho-amino or ortho-lower alkylamino; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy or lower alkanoyloxy; the pharmaceutically acceptable acid addition salts thereof and a process for the preparation thereof are described. The compounds of this invention are useful in the prevention of allergic and asthmatic reactions.

REFERENCES:
klingsberg, Pyridine and its Derivatives, Part Four, frontispage and pp. 54 to 58, Interscience Publishers (1964).
Burckhalter et al., J. Med. Chem., vol. 10, pp. 565 to 575 (1967).
Abramovitch et al., J. Org. Chem., vol. 37, pp. 1690 to 1696 (1972).
Al-Tai et al., Chemical Abstracts, vol. 69, abst. No. 106494d (1968).
Al-Tai et al., Chemical Abstracts, vol. 72, abst. No. 43,377g (1970).

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