.alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com

Details .alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com .alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com

1975-02-26

1976-12-21

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1916

Patent

active

039988066

ABSTRACT:
Treatment of the .alpha. and .beta. anomers of 2'-deoxy-6-selenoguanosine with alkyl halides, p-nitrobenzyl bromide, and 5-chloro-1-methyl-4-nitroimidazole under basic conditions has produced the desired products, which are 2'-deoxy-6-R-selenoguanosines where R is the substituent group [2-amino-6-R-seleno-9-(2-deoxy-.alpha.- and .beta.-D-erythro-pentofuranosyl)purines] and R is preferably lower alkyl or aryl. The animal test screening indicated substantial activity for several members of this group of compounds against mouse leukemia L-1210.

REFERENCES:
milne et al., "Jour. of Medicinal Chem.", 17, 1974, pp. 263-268.
Chu, "Chem. Abst.", vol. 74, 1971, p. 112375K.
Milne, "Biochem. Biophys. Acta", vol. 269, 1972, pp. 344-346.

Affiliated with

Also associated with

Rating

.alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1838303