.alpha.- and .beta.-2'-Deoxy-6-R-substituted selenoguanosine com

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives


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424180, C07H 1916




Treatment of the .alpha. and .beta. anomers of 2'-deoxy-6-selenoguanosine with alkyl halides, p-nitrobenzyl bromide, and 5-chloro-1-methyl-4-nitroimidazole under basic conditions has produced the desired products, which are 2'-deoxy-6-R-selenoguanosines where R is the substituent group [2-amino-6-R-seleno-9-(2-deoxy-.alpha.- and .beta.-D-erythro-pentofuranosyl)purines] and R is preferably lower alkyl or aryl. The animal test screening indicated substantial activity for several members of this group of compounds against mouse leukemia L-1210.

milne et al., "Jour. of Medicinal Chem.", 17, 1974, pp. 263-268.
Chu, "Chem. Abst.", vol. 74, 1971, p. 112375K.
Milne, "Biochem. Biophys. Acta", vol. 269, 1972, pp. 344-346.


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