Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters
Patent
1994-03-17
1996-04-16
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Phosphorus esters
558170, 558172, 562 15, 562 16, C07F 940, C07F 938
Patent
active
055084630
ABSTRACT:
Novel .alpha.-aminophosphonates are provided along with processes and intermediates for their preparation. In preferred embodiments, scalemic .alpha.-aminophosphonates are prepared by the stereoselective addition of phosphite salts to chiral imines.
REFERENCES:
patent: 3268450 (1966-08-01), Sims et al.
patent: 3314957 (1967-04-01), Friedman
patent: 3385914 (1968-05-01), Hindersinn et al.
Dale, et al., ".alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic Acid, a Versatile Reagent for the Determination of Enantiomeric Composition of Alcohols and Amines", J. Org. Chem., 34, 1969, 2543-2549.
Dhawan, et al., "Optically Active 1-Aminoalkylphosphonic Acids", Phosphorous and Sulfur, 1987, 32, 119-144.
Hanessian, et al., "A Versatile Asymmetric Synthesis of 60 -Amino .alpha.-.alpha.-Alkyl-Phosphonic Acids of High Enantiomeric Purity", Tetrahedron Letters, 1990, 31, 6465-6468.
Huber, et al., "Asymmetric Synthesis of .alpha.-Aminophosphonic Acids", Helvetica Chimica Acta, 1985, 68, 1730-1747.
Huber, et al., "Asymmetric Synthesis of N-Hydroxy-.alpha.-aminophosphonic and .alpha.-Aminophosphonic Acids", Helvetica Chimica Acta, 1987, 70, 1461-1476.
Ferrari, et al., "Asymmetric Synthesis of Diethyl .alpha.-Amino-.alpha.-Alkyl-Phosphonates by Alkylation of the Chiral Schiff Base Derived from (+)-Ketopinic Acid and Diethylaminomethyl Phosphonate", Synthetic Communications, 1992, 22(1), 107-123.
Yokomatsu, et al., "Enantioselective Synthesis of .alpha.-Amino Phosphonic Acids by an Application of Stereoselective Opening of Homochiral Dioxane Acetals with Triethyl Phosphite", Tetrahedron Asymmetry, 1992, 3, 377-378.
Jacquier, et al., "Synthesis of Enantiomerically Pure Aminophosphonic Acids", Phosphoprus and Sulfur, 1988, 36, 73-77.
Gilmore et al. "Synthesis of an Optically Active .alpha.-Aminophosphonic Acid", J. Am. Chem. Soc., 1972, 94, 4361.
Yuan, C. et al. Chemical Abstracts, vol. 121, No. 57895; Phosphorus, Sulfur Silicon Relat. Elem. 1993, 81(1-4), 27-35.
Li, S. et al. Chemical Abstracts, vol. 121, No. 35691; Huaxue Xuebao 1993 51(12), 1195-1202.
Smith, III Amos B.
Taylor Carol M.
Yager Kraig M.
Ambrose Michael G.
Richter Johann
Trustees of the University of Pennsylvania
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