Alpha-aminoamide derivatives as melanocortin agonists

Details Alpha-aminoamide derivatives as melanocortin agonists Alpha-aminoamide derivatives as melanocortin agonists

2005-07-12

2005-07-12

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S253010, C514S254090, C514S254100, C514S255010, C514S253060, C514S254050, C514S254080, C514S254110, C514S218000, C544S121000, C544S360000, C544S363000, C544S364000, C544S370000, C544S373000, C544S372000, C544S376000, C544S377000, C544S379000, C544S380000, C544S391000, C540S575000

Reexamination Certificate

active

06916812

ABSTRACT:
Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of the melanocortin receptors. The compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders such as obesity, diabetes, and sexual dysfunction.

REFERENCES:
patent: 5885999 (1999-03-01), Elliott et al.
patent: 2004/0053933 (2004-03-01), Pontillo et al.
patent: WO 99/64002 (1999-12-01), None
patent: WO 00/74679 (2000-12-01), None
Andersson et al. Expert Opin. Ther. Patents, vol. 11, pp. 1583-1592 (2001).
Sebhat et al. Annual Reports in Medicinal Chemistry, vol. 38, pp. 31-40 (2003).
Chen, W. et al., “Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides”,Cell91, pp. 789-798 (Dec. 1997).
Chhajlani, V. and Wikberg, J.E.S., “Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA”, J.E.,FEBS Lett., 309(3), pp. 417-420 (Sep. 1992).
Dorr, R.T., et al., “Evaluation of Melanotan-II, A Superpotent Cyclic Melanotropic Peptide in a Pilot Phase-I Clinical Study”,Life Sciences, 58(20), pp. 1777-1784 (1996).
Huszar, D., et al., “Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice”,Cell, 88, pp. 131-141 (Jan. 1997).
Mountjoy, K.G. et al., “The Cloning of a Family of Genes that Encode the Melanocortin Receptors”, Science, 257, pp. 1248-1251 (1997).
Wessells, H. et al., “Synthetic Melanotropic peptide Initiates Erections in Men with Psychogenic Erectile Dysfunction: Double-blind, Placebo Controlled Crossover Study”, J. Urology, 160, pp. 389-393 (1998).
Yen, T.Y. et al., “Obesity, diabetes, and neoplasia in yellow Avy/-mice: ectopic expression of theagoutigene”,The FASEB J, 8, pp. 479-488 (1994).

Affiliated with

Also associated with

Rating

Alpha-aminoamide derivatives as melanocortin agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alpha-aminoamide derivatives as melanocortin agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha-aminoamide derivatives as melanocortin agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3384111