.alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones

Details .alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones .alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylphenyl ketones

1975-07-18

1976-08-24

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603437, 26050111, 26050112, 26050118, 26050119, 2605706, 2605708R, 2605709, 260592, 424280, 424316, 424330, C07C 9710

Patent

active

039766942

ABSTRACT:
.alpha.-Aminoalkyl-4-hydroxy-3-alkylsulfonylmethylbenzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selected bronchodilators, are prepared from 4-hydroxyphenones by conversion to a 3-alkylsulfonylmethylphenone, bromination of these phenones and treatment of the resulting .alpha.-bromo derivatives with an N-benzyl secondary amine, followed by catalytic hydrogenation to remove the benzyl groups and reduce the ketone moiety.

REFERENCES:
patent: 3869474 (1975-03-01), Miura et al.

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