.alpha.-Amino sulfonyl hydroxamic acids as matrix metalloprotein

Details .alpha.-Amino sulfonyl hydroxamic acids as matrix metalloprotein .alpha.-Amino sulfonyl hydroxamic acids as matrix metalloprotein

1997-10-20

1998-09-08

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514575, 548494, 562623, A61K 3140, A61K 3119, C07D20912, C07D20918

Patent

active

058045937

ABSTRACT:
A compound of formula I or pharmaceutical acceptable salts thereof, ##STR1## wherein R.sub.1 is isopropyl, 2-methylbut-2yl, phenyl, benzyl, or 1H-indol-3ylmethyl; R.sub.2 is n-octyl, phenyl, or phenyl substituted with methoxy, fluoro, or bromo, are matrix metalloproteinase inhibitors.

REFERENCES:
MacPherson, L. J. at el. J. Med. Chem. vol. 40, pp. 2525-2523, (1997).

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