.alpha.-Amino methyl-5-hydroxy-2-pyridinemethanols

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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Details

2602948F, 2602948R, 260295S, 260296R, 260296B, 260296AE, C07D21338, A61K 3144

Patent

active

039521010

ABSTRACT:
.alpha.-Aminomethyl-5-hydroxy-2-pyridinemethanols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and finally catalytic hydrogenation to remove benzyl protective groups.

REFERENCES:
patent: 3558642 (1971-01-01), Hartley et al.
patent: 3700681 (1972-10-01), Barth

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