.alpha.-Amino ketone derivatives

Details .alpha.-Amino ketone derivatives .alpha.-Amino ketone derivatives

1976-11-09

1978-08-08

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424319, 260144, 260307R, 260349, 260516, 260519, 260558A, 560 12, 560 17, 560 29, 560 42, 544162, 544159, 544174, 544176, 544137, 544157, 544168, 544171, A61K 3124, C07C10104

Patent

active

041057902

ABSTRACT:
The invention concerns .alpha.-aminoacyl derivatives of phenyl-, phenoxy-, thiophenoxy- and phenylsulphinylalkanoic acids together with their amides, esters and pharmaceutically acceptable salts; processes for their preparation; and pharmaceutical compositions for therapeutic use in inhibiting the formation of thrombi and also in reducing the persistence of thrombi formed in the blood of warm blooded animals. Representative compounds of the invention are methyl 4-(aminoacetyl)phenoxyacetate, 4-(aminoacetyl)phenoxyacetic acid and methyl 4-(aminoacetyl)-thiophenoxyacetate, preferably as their hydrochlorides.

REFERENCES:
patent: 3914286 (1975-10-01), Mieville
Niederl et al., J. of Organic Chem. 1952, 11, 1617-1620.
Gorini et al., Chem. Abst. 3399(a), vol. 60, 1964.
Valcavi, Chem. Absts. 6778(g), vol. 60, 1964.
Wolff et al., Chem. Absts. 31318(g), vol. 82, 1975.

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