Alpha-amino acid derivatives with antiinflammatory activity

Details Alpha-amino acid derivatives with antiinflammatory activity Alpha-amino acid derivatives with antiinflammatory activity

2005-06-07

2009-12-22

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

C514S355000, C514S464000, C514S575000, C546S316000, C549S436000

Reexamination Certificate

active

07635788

ABSTRACT:
Compounds of the formula:are described in which Z, Q, X, L, m and n assume the meanings stated in the description. The compounds (I) inhibit the production of TNF α and may thus be useful in the treatment of inflammation and pathological conditions involving overproduction of said cytokine. They furthermore exhibit significant inhibitory activity on the proliferation of tumour cells and may thus be used for the treatment and/or prevention of tumorous, neurodegenerative or autoimmune disorders.

REFERENCES:
patent: 6034096 (2000-03-01), Bertolini et al.
patent: 7420089 (2008-09-01), Verner et al.
patent: WO 02/26696 (2002-04-01), None

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