.alpha.,.alpha.-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide,

Details .alpha.,.alpha.-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, .alpha.,.alpha.-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide,

1986-07-23

1989-04-25

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142355, 514316, 514326, 544130, 546188, 546208, 546217, A61K 31445, C07D21194

Patent

active

048248533

ABSTRACT:
Antidiarrheal active .alpha.,.alpha.-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides, compositions containing the same and methods of treating diarrhea.

REFERENCES:
patent: 3714159 (1973-01-01), Janssen et al.
patent: 3843646 (1974-10-01), Kreider
patent: 3892776 (1975-07-01), Hook et al.
patent: 4086345 (1978-04-01), Garzia et al.
patent: 4277605 (1981-07-01), Buyniski et al.
patent: 4306069 (1981-12-01), Lawson
M. H. Bickel, "The Pharmacology and Biochemistry of N-Oxides", (1969) Pharmacological Reviews, vol. 21, No. 4, pp. 325-355.
Carlos J. E. Niemegeers et al., Drug Development Research, vol. 8 (1986), pp. 279-286.
K. D. Stahl et al., European Journal of Pharmacology, vol. 46 (1977), pp. 199-205.

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