.alpha.,.alpha.-Dialkyl-4-phenethyl-benzylamines and the salts t

Details .alpha.,.alpha.-Dialkyl-4-phenethyl-benzylamines and the salts t .alpha.,.alpha.-Dialkyl-4-phenethyl-benzylamines and the salts t

1975-10-23

1977-04-12

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465R, 260471R, 260471C, 260556AR, 2605011, 26050118, 260558R, 260558D, 260562P, 260665G, 260551R, 424316, 424330, C07C 8728

Patent

active

040175430

ABSTRACT:
This application discloses methods of preparing .alpha.,.alpha.-diloweralkyl substituted benzylamines by the catalytic hydrogenation of the corresponding .alpha.,.alpha.-dialkyl-4-(phenyl-ethynyl)-benzylamine. The produced .alpha.,.alpha.-diloweralkylamines are converted to the corresponding N-alkyl and N,N-dialkyl derivatives thereof. The amines and their alkylated derivatives are useful as antiarrhythmics.

REFERENCES:
patent: 3309404 (1967-03-01), Engelhardt
patent: 3719712 (1973-03-01), Remy
patent: 3780106 (1974-05-01), Trent et al.
patent: 3819723 (1974-06-01), Dvolaitzky et al.
Klein et al., "Journal Organic Chemistry", vol. 32, pp. 1155-1160 (1967).

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