Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1984-06-27
1986-07-01
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530385, 530405, 530406, 424101, A61K 3514, C07K 1300
Patent
active
045980640
ABSTRACT:
Blood substitute and blood plasma expanders comprising alpha-alpha cross-linked stroma-free hemoglobin, which is substantially free of hemoglobin derivatives modified at other sites. The hemoglobin composition is intramolecularly cross-linked between Lys 99 Alpha.sub.1 and Lys 99 Alpha.sub.2.
REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4136093 (1979-01-01), Bonhard et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4376059 (1983-03-01), Davis et al.
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4473494 (1984-09-01), Tye
patent: 4473496 (1984-09-01), Scannon
patent: 4529719 (1985-07-01), Tye
Biochemistry, 11 No. 19 (1972), 3576-3582, Benesch et al.
Biochem-Biophys. Res. Communications, 63, No. 4 (1975), 1123-1129, Benesch et al.
Fed. Proc. 34, No. 6, (1975), 1458-1460, Mok et al.
Walder, et al., J. Mol. Biol. (1980) 141, 195-216, "Development of Antisickling Compounds that Chemically Modify Hemoglobin S Specifically within the 2,3-Diphosphoglycerate Binding Site".
1982 FASEB Abstract Form.
R. W. Tye, et al., Advances in Blood Substitute Research (1983) pp. 41-49, "Modification of Hemoglobin--Tetrameric Stabilization".
Fronticelli et al., Advances in Blood Substitute Research (1983) pp. 51-57, "Neohemoglobins as Blood Substitutes".
Schain Howard E.
University of Iowa Research Foundation
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