Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

Details Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

1985-03-11

1987-09-15

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

260413, A61K 3120, C07C 5703

Patent

active

046940235

ABSTRACT:
Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.
The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

REFERENCES:
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patent: 4021573 (1977-05-01), Lee
patent: 4048204 (1977-09-01), Lee
patent: 4472430 (1984-09-01), Loev et al.
patent: 4505930 (1985-03-01), Loev et al.
patent: 4545977 (1985-10-01), Gavll
Haeck et al., Chemical Abstracts, vol. 65, No. 3915 C, (1966).
Chem. Abstracts 79: 52873n, Lee.
Chem. Abstracts 85: 137587w, Lee.
J.A.C.S., vol. 96, No. 11, pp. 3642-3644, Nakanishi et al.
Chem. Abstracts 85: 13674c, Lee et al.

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