Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

Details Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

1982-06-28

1984-09-18

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424308, 424318, 424320, 424324, 424DIG4, 2604109R, 260413, 260404, A61K 31215, A61K 3120, C07C 5703, C07C 69587

Patent

active

044724306

ABSTRACT:
Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2,NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.
The foregoing compounds have been found to be effective in the treatment of psoriasis.

REFERENCES:
patent: 3934028 (1976-01-01), Lee
patent: 4021573 (1977-05-01), Lee
Haeck, H. H. et al., Rec. Trav. Chim., 85 (1966) 334-338.
Kligman, Lorraine et al., J. Investigative Dermatology, vol. 73 (1979) pp. 354-358.
Marcelo, Cynthia L. et al., J. Cell Biology, vol. 79, (1978) pp. 356-370.
Ballag, Werner, Chemical Abstracts, vol. 75 (1971) #67486e.
Mills, O. H. et al., Assay of Comedolytic Agents in the Rabbit Ear, Animal Models in Dermatology; Relevance to Human Dermatopharmacology and Dermatology, Maibach, H. J., ed., New York, Churchill-Livingston, Publ. (1975) pp. 176-183.

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