Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

Details Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo Alpha-alkyl polyolefinic carboxylic acids and derivatives thereo

1983-07-08

1985-03-19

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

424 45, 514557, 514613, A61K 3116, A61K 3120, A61K 3123, A61L 904

Patent

active

045059306

ABSTRACT:
Polyolefinic compounds represented by the general formula ##STR1## in which R and R.sub.1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R.sub.2 is an alkyl group of from 1 to 5 carbon atoms; R.sub.3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH.sub.2, NHR.sub.2 or NR.sub.2 R.sub.2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof.
The foregoing compounds have been found to be effective in the treatment of psoriasis, inflammatory conditions and allergic responses.

REFERENCES:
patent: 3934028 (1976-01-01), Lee
patent: 4021573 (1977-05-01), Lee

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