.alpha.-Acetylenic derivatives of histamine and related compound

Details .alpha.-Acetylenic derivatives of histamine and related compound .alpha.-Acetylenic derivatives of histamine and related compound

1977-07-01

1978-07-11

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, 544 28, 548342, C07D23364

Patent

active

041003497

ABSTRACT:
Novel acetylenic derivatives of amines of the following general structure ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR2## wherein R.sub.3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R.sub.1 and R.sub.2 is hydrogen, halogen selected from fluorine, chlorine, bromine and iodine or a straight or branched lower alkyl group of from 1 to 4 carbon atoms and may be the same or different with the proviso that when both R.sub.1 and R.sub.2 are halogen R.sub.1 and R.sub.2 are the same; and pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
patent: 3169971 (1965-02-01), Sletzinger et al.
patent: 3387031 (1968-06-01), Johnson et al.

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