Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1978-10-02
1980-02-26
Lee, Mary C.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
546221, 546243, 424207, 424274, 562571, C07D20726, C07D21176
Patent
active
041905865
ABSTRACT:
Novel acetylenic derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein n is an integer of from 1 to 3; R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; and the lactams thereof when n is 2 or 3; and pharmaceutically acceptable salts and individual optical isomers thereof.
REFERENCES:
patent: 3255112 (1966-06-01), Hoffman et al.
patent: 3959356 (1976-05-01), Metcalf et al.
patent: 4041041 (1977-08-01), Metcalf et al.
patent: 4147873 (1979-04-01), Metcalf et al.
Jung Michel
Metcalf Brian W.
Hattan L. Ruth
Lee Mary C.
Merrell Toraude et Compagnie
Rauchfuss, Jr. George W.
Retter Eugene O.
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