.alpha.-Acetylenic derivatives of .alpha.-amino acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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2601125R, 424320, 424309, 424313, 424314, 424319, 424246, 560157, 560159, 560169, 560171, 562444, 562448, 562443, 562561, 562563, 544 19, 544 30, 542419, 564153, C07C10120, C07C10126, C07C10128, C07C10172

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042608236

ABSTRACT:
Novel acetylenic derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## is hydrogen, a straight or branched lower alkyl group of 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; and pharmaceutically acceptable salts and individual optical isomers thereof.

REFERENCES:
patent: 2662915 (1953-12-01), Lontz et al.
patent: 4041041 (1977-08-01), Metcalf et al.
Relyea et al., Biochem., Biophysics Res. Comm., 1975, 67(1), pp. 392-402.
Rando, Science, vol. 185, pp. 320-324 (1974).
Carlyle et al., Chem. Abst., vol. 80, #106132m, (1974).

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