Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
2601125R, 424320, 424309, 424313, 424314, 424319, 424246, 560157, 560159, 560169, 560171, 562444, 562448, 562443, 562561, 562563, 544 19, 544 30, 542419, 564153, C07C10120, C07C10126, C07C10128, C07C10172
Novel acetylenic derivatives of .alpha.-amino acids of the following general structure: ##STR1## wherein R is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR2## is hydrogen, a straight or branched lower alkyl group of 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; each R.sub.1 is the same and is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.3 R.sub.4 wherein each of R.sub.3 and R.sub.4 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms and can be the same or different, or ##STR3## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; and pharmaceutically acceptable salts and individual optical isomers thereof.
patent: 2662915 (1953-12-01), Lontz et al.
patent: 4041041 (1977-08-01), Metcalf et al.
Relyea et al., Biochem., Biophysics Res. Comm., 1975, 67(1), pp. 392-402.
Rando, Science, vol. 185, pp. 320-324 (1974).
Carlyle et al., Chem. Abst., vol. 80, #106132m, (1974).
Casara Patrick J.
Metcalf Brian W.
Conte Salvatore R.
Kolano John J.
McDonald Raymond A.
Merrell Toruade et Compagnie
Reamer James H.
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