Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-07-01
1978-07-25
Trousof, Natalie
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548337, 544 28, 424273R, C07D23364
Patent
active
041030893
ABSTRACT:
Novel acetylene and vinyl derivatives of amino acids of the following general structure ##STR1## wherein R is --CH.dbd.CH.sub.2 or C.tbd.CH; R.sub.1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.11 R.sub.12 wherein each of R.sub.11 and R.sub.12 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms, ##STR2## wherein R.sub.5 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR3## wherein R.sub.6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; each of R.sub.3 and R.sub.4 is hydrogen, halogen selected from fluorine, chlorine, bromine and iodine, or a straight or branched lower alkyl of from 1 to 4 carbon atoms and may be the same or different with the proviso that when both R.sub.3 and R.sub.4 are halogen R.sub.3 and R.sub.4 are the same; with the proviso that when R is --CH.dbd.CH.sub.2, R.sub.1 is hydroxy and R.sub.2 is hydrogen; and pharmaceutically acceptable salts thereof.
REFERENCES:
patent: 3169971 (1965-02-01), Sletzinger et al.
patent: 3387031 (1968-06-01), Johnson et al.
Jung Michel
Metcalf Brian Walter
Hattan L. Ruth
Merrell Toraude et Compagnie
Rauchfuss, Jr. George W.
Retter Eugene O.
Trousof Natalie
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