Alpha-3 chain type IV collagen polypeptides

Details Alpha-3 chain type IV collagen polypeptides Alpha-3 chain type IV collagen polypeptides

1998-10-07

1999-12-28

Leary, Louise N.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 71, 530326, 530395, 536 235, C12Q 100

Patent

active

060079800

ABSTRACT:
An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome.

REFERENCES:
patent: 4876332 (1989-10-01), Tsilibary et al.
patent: 4985542 (1991-01-01), Fillit et al.
patent: 5424408 (1995-06-01), Reeders et al.

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