.alpha.-3 chain type IV collagen polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 235, C07K 1447

Patent

active

059731206

ABSTRACT:
An isolated and substantially pure polynucleotide encoding 238 amino acids of the carboxy terminal end of the triple helical domain and all 233 amino acids of the carboxy terminal noncollageneous domain of the bovine .alpha.3 chain of type IV collagen. An isolated and substantially pure polynucleotide encoding 218 amino acids of the carboxy terminal noncollagenous domain of the human .alpha.3 chain of type IV collagen. Such polynucleotides are useful to express large amounts of proteins in vectors and such expressed proteins are useful to detect Goodpasture antibodies in blood and to remove Goodpasture antibodies from the bloodstream of patients suffering from Goodpasture syndrome. GOVERNMENT RIGHTS

REFERENCES:
patent: 4394443 (1983-07-01), Weissman et al.
patent: 4800159 (1989-01-01), Mullis et al.
Butkowski et al, J. Lab. Clin Med., 115, (1990), pp. 365-373 "Characterization of type IV collagen NC1 monomers and Goodpasture antigen in human renal basement membranes".
Saus et al, The Journal of Biological Chemistry, 263, (1988), pp. 13374-13380, "Identification of the Goodpasture Antigen as the .alpha.2(IV) Chain of Collagen IV".
Morrison et al, The Journal of Biological Chemistry, 266, (1991), pp. 34-39, "Use of the Polymerase Chain Reaction to Clone and Sequence a cDNA Encoding the Bovine .alpha.2 Chain of Type IV Collagen".
Dion et al, J. Mol. Biol., (1987) 193, pp. 127-143, "COOH-terminal Propeptide of the Major Human Procollagens Structural, Functional and Genetic Comparisons".
Erkki Soini et al, Clinical Chemistry, vol. 25, No. 3, 1979 pp. 353-361, "Fluoroimmunoassay: Present Status and Key Problems".
Taina Pihlajaniemi et al, The Journal of Biological Chemistry, vol. 265, No. 23, pp. 13758-13766, 1990, "Complete Primary Structure of the Triple-helical Region and the Carboxyl-terminal Domain of a New Type IV Collagen Chain, .alpha.5(IV)".
Feinberg et al, Analytical Biochemistry, 132, pp. 6-13 (1983), "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specifc Activity".
McCoy et al, Kidney International, vol. (1982), pp. 642-652, "Absence of nephritogenic GBM antigen(s) in some patients with hereditary nephritis".
Brinker et al, Proc. Natl. Acad. Sci. USA, vol. 82, pp. 3649-3653, Jun. 1985, Biochemistry, "Restricted homology between .alpha.1 type IV and other procollagen chains".
U.K. Laemmli, Nature, vol. 227, (1970) "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4" pp. 680-685.
Piotr Chomzczynski et al, Analytical Biochemistry, 162, pp. 156-159, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction".
Timpl et al, J. Biochem., 120, pp. 203-211, (1981), "A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes".
Martin et al, Advances in Protein Chemistry, vol. 39, (1988) pp. 1-51, "Basement Membrane Proteins: Molecular Structure and Function".
Timpl, Eur. J. Biochem. 180, 487-502 (1989), "Structure and Biological activity of basement membrane proteins".
Hostikka et al, The Journal of Biological Chemistry, vol. 263, No. 36, (1988), pp. 19488-19493, "The Complete Primary Structure of the .alpha.2 Chain of Human Type IV Collagen and Comparison with the .alpha.1(IV) Chain".
Muthukumaran et al, The Journal of Biological Chemistry, vol. 264, No. 11 (1989) pp. 6310-6317, "The Complete Primary Structure for the .alpha.1-Chain of Mouse Collagen IV".
Saus et al, The Journal of Biological Chemistry, vol. 264, (1989), pp. 6318-6324, "The Complete Primary Structure of Mouse .alpha.2(IV) Collagen".
Blumberg et al, The Journal of Biological Chemistry, vol. 263, No. 34, (1988), pp. 18328-18337, "Drosophila Basement Membrane procollagen .alpha.1(IV)".
Butkowski et al, The Journal of Biological Chemistry, vol. 260, No. 6, (1985), pp. 3739-3747, "Properties of the Globular Domain of Type IV Collagen and Its Relationship to the Goodpasture Antigen".
Wieslander et al, The Journal of Biological Chemsitry, vol. 260, No. 260, No. 14, (1985), pp. 8564-8570, "Physical and Immunochemical Studies of the Globular Domain of Type IV Collagen".
Butkowski et al, The Journal of Biological Chemistry, vol. 262, No. 16 (1987) pp. 7874-7877, "Localization of the Goodpasture Epitope to a Novel Chain of Basement Membrane Collagen".
Hudson et al, Laboratory Investigation, vol. 61, No. 3 pp. 256-269, (1989), "Biology of Disease Goodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen".
Kleppel et al, The Journal of Biological Chemistry, vol. 261, No. 35, (1986), pp. 16547-16552, "Antibody Specificity of Human Glomerular Basement Membrane Type IV Collagen NC1 Subunits".
Jeraj et al, American Journal of Kidney Diseases, vol. 11, No. 6, (1983), "Absence of Goodpasture's Antigen in Male Patients With Familial Nephritis".
Kashtan et al, J. Clin. Invest., vol. 78, (1986), pp. 1035-1044, Nephritogenic Antigen Determinants in Epidermal and Renal Basement Membranes of Kindreds with Alport-type Familial Nephritis.
Jenis et al, Clinical Nephrology, vol. 15, No. 3 (1981) pp. 111-114, "Variability of anti-GBM binding in hereditary nephritis".
Olson et al, The Journal of Pediatrics, vol. 96, (1980) pp. 697-699, "Diagnosis of Hereditary nephritis by failure of glomeruli to bind anti-glomerular basement membrane antibodies".
Savage et al, Kidney International, vol. 30, (1986) pp. 107-112, "The Goodpasture antigen in Alport's syndrome: Studies with a monoclonal antibody".
Hostikka et al, Proc. Natl. Acad. Sci. USA, vol. 87, (1990) pp. 1606-1610, "Identification of a distinct type IV collagen .alpha. chain with restricted kidney distributin and assignment of its gene to the locus of X chromosome-linked Alport syndrome".
Myers et al, Am. J. Hum. Genet., 46:1024-1033, (1990), pp. 1024-1033, "Molecular Cloning of .alpha.5(IV) Collagen and Assignment of the Gene to the Region of the X Chromosome Containing the Alport Syndrome Locus".
Atkin et al, Am. J. Hum. Genet., 42:249-255, (1988), pp. 249-255, "Mapping of Alport Syndrome to the Long Arm of the X Chromosome".
Brunner et al, Kidney International, vol. 34, (1988), pp. 507-510. "Localization of the gene for X-linked Alport's syndrome".
Flinter et al, Genomics, vol. 4, pp. 335-338 (1989), "Localization of the Gene for Classic Alport Syndrome".
Barker et al, Science, vol. 248, pp. 1224-1227, (1990), "Identification of Mutations in the COL4A5 Collagen Gene in Alport Syndrome".
Pihlajaniemi et al, The Journal of Biological Chemistry, vol. 260, No. 12, (1985), pp. 7681-7687, "cDNA Clones Coding for the Pro-.alpha.1 (IV) Chain of Human Type IV Procollagen Reveal an Unusual Homologyof Amino Acid Sequences in Two Halves of the Carboxyl-terminal Domain".
Gunwar et al, The Journal of Biological Chemistry, vol. 265, No. 10, (1990), pp. 5446-5469, "Glomerular Basement Membrane".
Grunfeld, Kidney International, vol. 27, (1985), pp. 83-92, "The clinical spectrum of hereditary nephritis".
Hinglais, et al, Laboratory Investigation, vol. 27, (1972) No. 5, pp. 473-487, "Characteristic Ultrastructural Lesion of the Glomerular Basement Membrane in Progressive Hereditary Nephritis (Alport's Syndrome)".
Yoshikawa et al, J. Pathology, vol. 135, (1981), 199-209, "The Glomerular Basal Lamina in Hereditary Nephritis".
Henry et al, Clinical Chemistry, vol. 22, No. 7, 1976, p. 1232, "Debate on the Procedure of Rao et al for Creatine Kinase".
S. Szpiro-Tapia et al, Hum. Genet., (1988) vol. 81, pp. 85-87, "Linkage studies in X-linked Alport's syndrome".
Kleppel et al, J. Clin. Invest., vol. 80, (1987), pp. 263-265, "Alport Familial Nephritis Absence of 28 Kilodalton Non-Collagenous Monomers of Type IV Collagen in Glomerular Basement Membrane".
Soininen et al, Febs Letters, vol. 225, No. 1,2, pp. 188-194, (1987), "Complete primary structure of the .alpha.1-chain of human basement membrane (type IV) collagen".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

.alpha.-3 chain type IV collagen polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.-3 chain type IV collagen polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-3 chain type IV collagen polypeptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-766134

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.