Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-05-01
2007-05-01
Shukla, Ram R. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023500
Reexamination Certificate
active
10638714
ABSTRACT:
The present invention includes polymorphisms in nucleic acids encoding the alpha-2A adrenergic receptor and expressed alpha-2A adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms and transgenic animals expressing alpha-2A adrenergic receptor molecules. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system diseases.
REFERENCES:
patent: 5595880 (1997-01-01), Weinshank et al.
patent: 5648482 (1997-07-01), Meyer
patent: 5846710 (1998-12-01), Bajaj
patent: 5856092 (1999-01-01), Dale et al.
patent: 5888819 (1999-03-01), Goelet et al.
patent: 5981174 (1999-11-01), Wolf et al.
patent: 6004744 (1999-12-01), Goelet et al.
patent: 6013431 (2000-01-01), Soderlund et al.
patent: 6156503 (2000-12-01), Drazen et al.
patent: WO 0129082 (2001-04-01), None
Idoia Martin-Guerrero et al. The N251K function polymoprhism in the alpha-2A adrenoceptor gene is not associated with depression: a study in suicide completers. Dec. 2005, Pyschopharmacology vol. 184: 82-86.
Kersten Small et al. Identification and functional characterization of alpha-2 adrenoceptor polymorphisms. Sep. 2001, TRENDS in Pharmacological Sciences vol. 222, No. 9, 471-477.
Heinonen P. et al: “Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”The Journal of Clinical Endocrinology and Metabolism, United States, Jul. 1999, vol. 84, No. 7, pp. 2429-2433.
Baldwin C.T., et al: “Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension.”American Journal of Hypertension: Journal of the American Society of Hypertension, United States, Sep. 1999, vol.12, No. 9, Pt. 1, pp. 853-857.
Jewell-Motz, E.A. et al: “An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization.”Biochemistry, United States Sep. 19, 1995, vol. 34, No. 37, Sep. 19, 1995, pp. 11946-11953.
Comings, D.E., et al: “Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects.”Clinical Genetics, Denmark, Mar. 1999, vol. 55, No. 3, pp. 160-172.
Makaritsis K.P., et al: “Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.”Hypertension. United States, Jan. 1999, vol. 33, No. 1, Jan. 1999, pp. 14-17.
Michel M.C., et al: “Functional correlates of alpha(2A)-adrenoceptor gene polymorphism in the HANE study.”Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association. England, Nov. 1999, vol. 14, No. 11, pp. 2657-2663.
Freeman K., et al: “Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.”American Journal of Hypertension: Journal of the American Society of Hypertension. United States, Sep. 1995, vol. 8, No. 9, pp. 863-869.
Small K.M., et al: “Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.”The Journal of Biological Chemistry, United States, Feb. 16, 2001, vol. 276, No. 7, pp. 4917-4922.
Snapir A., et al: “An insertion/deletion polymorphism in the alpha2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events.”Journal of the American College of Cardiology. United States, May 2001, vol. 37, No. 6, pp. 1516-1522.
Limbird, L.E. (1988) FASEB J 2, 2686-2695.
Luttrell, L.M., van Biesen, T., Hawes, B.E., Della Rocca, G.J., Luttrell, D.K., and Lefkowitz, R.J. (1998) in Catecholamines: Bridging Basic Science with Clinical Medicine (Goldstein, D.S., Eisenhofer, G., and McCarty, R., eds) pp. 466-470, Academic Press.
Ruffolo, R.R., Jr., Nicholas, A.J., Stadel, J.M., and Hieble, J.P. (1993) Annu Rev Pharmacol Toxicol 32, 243-279.
Hein, L., Altman, J.D., and Kobilka, B.K. (1999) Nature 402, 1810-184.
Altman J.D., Trendelenburg, A.U., MacMillan, L., Bernstein, D., Limbird, L., Starke, K., Kobilka, B.K., and Hein, L. (1999) Mol.Pharmacol. 56, 154-161.
Lakhlani, P.P., MacMillan, L.B., Guo, T.Z., McCool, B.a., Lovinger, D.M., Maze, M., and Limbird, L.E. (1997) Proc Natl Acad Sci USA 94, 9950-9955.
Holmes, B., Brogden, R.N., Heel, R.C., Speight, T.M., and Avery, G.S. (1983) Drugs 26, 212-229.
Dao, T.T., Kailasam, M.T., Parmer, R.J., Le, H.V., Le Verge, R., Kennedy, B.P., Ziegler, G., Insel, P.A., Wright, F.A., and O'Connor, D.T. (1998) J Hypertens 16, 779-792.
Goldstein, D.S., Grossman, E., Listwak, S., and Folio, C.J. (1991) Hypertension 18, III40-III48.
Lockette, W., Ghosh, S., Farrow, S., MacKenzie, S., Baker, S., Miles, P., Schork, A., and Cadaret, L. (1995) Am J Hypertens 8, 390-394.
Svetkey, L.P., Timmons, P.Z., Emovon, O., Anderson, N.B., Preis, L., and Chen, T.-T. (1996) Hypertension 27, 1210-1215.
Liggett, S.B. (1998) Clin and Exp.Allergy 28, 77-79.
Guyer, C.A., Horstman, D.A., Wilson, A.L., Clark, J.D., Cragoe, E.J.Jr., and Limbird, L.E. (1990) J Biol Chem 265, 17307-17317.
Rutkowski, M.P., Klanke, C.A., Su, Y.R., Reif, M., and Menon, A.G. (1998) Hypertension 31, 1230-1234.
Eason, M.G. and Liggett, S.B. (1992) J.Biol.Chem. 267, 25473-25479.
Jewell-Motz, E.A. and Liggett, S.B. (1996) J.Biol.Chem 271, 18082-18087.
de chasseval, R. and de Villartay, J.-P. (1991) Nucleic Acids Research 20, 245-250.
Eason, M.G., Moreira, S.P., and Liggett, S.B. (1995) J.Biol. Chem. 270, 4681-4688.
Jewell-Motz, E.A., Donnelly, E.T., Eason, M.G., and Liggett, S.B. (1998) Biochem 37, 15720-15725.
Schwinn, D.A., Page, S.O., Middleton, J.P., Lorenz, W., Liggett, S.B., Yamamoto, K., Carou, M.G., Lefkowitz, R.J., and Cotecchia, S. (1991) Mol. Pharmacol. 40, 619-626.
Martin, T.F.J. (1983) J Biol Chkem 258, 14816-14822.
Eason, M.G., Jacinto, M.T., Theiss, C.T., and Liggett, S.B. (1994) Proc.Natl.Acad.Sci., USA 91, 11178-11182.
Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J., and Klenk, D.C. (1985) Anal.Biochem. 150, 76-85.
Eason, M.G. and Liggett, S.B. (1996) J.Biol.Chem. 271, 12826-12832.
Exton, J.H. (1996) Annu Rev Pharmacol Toxicol 36, 481-509.
MacMillan, L.B., Lakhlani, P., Lovinger, D., and Limbird, L.E. (1998) Recent Prog Horm Res 53, 25-42.
Makaritsis, K.P., Johns, C., Gavras, I., Altman, J.D., Handy, D.E., Brenshan, M.R., and Gavras, H. (1999) Hypertension 34, 403-407.
Spiegel, A.M. (1996) Annu Rev Physiol 58, 143-170.
Kotanko, P., Binder, A., Tasker, J., DeFreitas, P., Kamdar, S./, Clark, A.J., Skrabal, F., and Caulfield, M. (1997) Hypertension 30, 773-776.
Liggett, S.B., Wagoner, L.E., Craft, L.L., Hornung, R.W., Hoit, B.D., McIntosh, T.C., and Walsh, R.A. (1998) J. Clin Invest 102, 1534-1539.
Tan, S., Hall, L.P., Dewar, J., Dow, E., and Lipworth, B. (1997) Lancet 350, 995-999.
Green, S.A., Cole, G., Jacinto, M., Innis, M., and Liggett, S.B. (1993) J Biol Chem 268, 23116-23121.
Shenker, A., Laue, L., Kosugi, S., Mcrendino, J.J., Minegishi, T., and Cutler, G.B. (1993) Nature Lond 365, 652-654.
Fraser, C.M. et al. Cloning, sequence analysis, and permanent expression of a human alpha2-adrenergic receptor in Chinese hamster ovary cells. The Journal of Biological Chemistry 264(20): 11754-11761 (Jul. 1989).
Feng, J. et al. Variants in the alpha2A AR adrenergic receptor gene in psychiatric patients. American Journal of Medical Genetics (Neuropsychiatric Genetics) 81:405-410 (1998).
Guyer, C.A. et al. Cloning, sequencing, and expression of the gene encoding the procine alpha2-adrenergic receptor. The Journal of Biological Chemistry 265(28):17307-17317 (Oct. 199
Liggett Stephen B.
Small Kersten M.
Fenwick & West
Shaw Amanda
Shukla Ram R.
University of Cincinnati
LandOfFree
Alpha-2A-adrenergic receptor polymorphisms does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alpha-2A-adrenergic receptor polymorphisms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alpha-2A-adrenergic receptor polymorphisms will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3805481