Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1996-04-10
1999-07-27
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
435 691, 435 711, 4352523, 435325, 4353201, 530356, 536 232, C12N 1553, C12N 1512, C12N 1563, C12N 510
Patent
active
059289228
ABSTRACT:
The present invention relates to novel isoforms of the .alpha. subunit of prolyl-4-hydroxylase, polynucleotide sequences encoding these novel proteins, and methods for making such proteins.
REFERENCES:
Bassuk et al., 1989, "Prolyl-hydroxylase: Molecular Cloning and the Primary Structure of the .alpha. Subunit from Chicken Embryo", Proc. Natl. Acad. Sci. U.S.A. 86:7382-886.
Caruthers et al., 1980, "New Chemical Methods for Synthesizing Polynucleotides", Nucleic Acids Res. Symp. Ser. 7:215-233.
Cheng et al., 1987, "The Nucleotide Sequence of a Human Cellular Thyroid Hormone Binding Protein Present in Endoplasmic Reticulum", J. Biol. Chem. 262:11221-27.
Chow et al., 1981, "Synthesis of Oligodeoxyribonucleotides on Silica Gel Support", Nucleic Acids Res. 9:2807-2817.
Crea and Horn, 1980, "Synthesis of Oligonucleotides on Cellulose by a Phosphotriester Method", Nucleic Acids Res. 9:2331.
Freedman et al., 1994, "Protein Disulphide Isomerase: Building Bridges in Protein Folding", Trends Biochem. Sci 19:331-336.
Heineg.ang.rd and Oldberg, 1989, "Structure and Biology of Cartilage and Bone Matrix Noncollagenous Macromolecules", FASEB J. 3:2042-2051.
Helaakoski et al., 1989, "Molecular Cloning of the .alpha.-subunit of human prolyl 4-hydroxylase: The Complete cDNA-derived Amino Acid Sequence and Evidence for Alternative Splicing of RNA Transcripts", Proc. Natl. Acad. Sci. U.S.A. 86:4392-96.
Helaakoski et al., 1994, "Structure and Expression of the Human Gene for the .alpha.Subunit of Prolyl 4-Hydroxylase", J. Biol. Chem. 269:27874-854.
Helaakoski et al., 1995, "Cloning, Baculovirus Expression, and Characterization of a Second Mouse Prolyl 4-Hydroxylase .alpha.-subunit Isoform: Formation of an .alpha..sub.2 .beta..sub.2 Tetramer with the Protein Disulfide-isomerase/.beta. subunit", Proc. Natl. Acad. Sci. U.S.A. 92:4427-4431.
John, et al., 1993, "Cell-free Synthesis and Assembly of Prolyl 4-hydroxylase: The Role of the .beta.-subunit (PDI) in Preventing Misfolding and Aggregation of the .alpha.-subunit", EMBO J. 12:1587-1595.
Kivirriko and Myllya, 1982, "Posttransitional Enzymes in the Biosynthesis of Collagen: Intracellular Enzymes", Methods. Enzymol. 82:245-304.
Kivirikko et al., 1989, "Protein Hydroxylation: Prolyl 4-hydroxylase, an Enzyme with Four Cosubstrates and a Multifunctional Subunit", FASEB J. 3:1609-1671.
Kivirikko et al., 1990, "Molecular Biology of Prolyl 4-hydroxylase", Ann. N.Y. Acad. Sci. 580:132-142.
M.J.C. (CRC, Boca Raton, FL) pp. 1-51.
Koivu et al., 1987, "A Single Polypeptide Acts Both as the .beta.Subunit of Prolyl 4-hydroxylase and as a Protein Disulfide-isomerase", J. Biol. Chem. 262:6447-49.
MacNeil et al., 1993, "Isolation of a cDNA Encoding Thymic Shared Antigen-1", J. Immunol. 151:6913-23.
Matteucci and Caruthers, 1980, "The Synthesis of Oligodeoxypyrimidines on a Polymer Support", Tetrahedron Letters 21:719-722.
Mayne et al., 1993, "Cartilage Degradation: Basic and Clinical Aspects," (Woessner, J.F. and Howell, D.S., eds.) Marcel Dekker, Inc. New York pp. 81-108.
Myllyla et al., 1977, "Mechanism of the Prolyl Hydroxylase Reaction", Eur. J. Biochem. 80:349-357.
Myllyla et al., 1992, "Modification of Vertebrate and Algal Prolyl 4-hydroxylases and Vertebrate Lysyl Hydroxylase by Diethyl Pyrocarbonate", Biochem. J. 286:923-927.
Noiva et al., 1991, "Peptide Binding by Protein Disulfide Isomerase a Resident Protein of the Endoplasmic Reticulum Lumen", J. Biol. Chem. 266:19645-649.
Noiva and Lennarz, 1992, "Protein Disulfide Isomerase", J. Biol. Chem. 267:3553-3556.
Noiva et al., 1993, "Peptide Binding to Protein Disulfide Isomerase Occurs at a Site Distinct from the Active Sites", J. Biol. Chem. 268:19210-217.
Pihlajaniemi et al., 1987, "Molecular Cloning of the .beta.-subunit of Human Prolyl 4-hydroxylase. This Subunit and Protein Disulphide Isomerase are Products of the Same Gene", EMBO J. 6:643-649.
Veijola et al., 1994, "Cloning, Baculovirus Expression, and Characterization of the .alpha. Subunit of Prolyl 4-hydroxylase from the Nematode Caenorhabditis elegans", J. Biol. Chem. 269::26746-753.
von Hejne, G., 1986, "A New Method for Predicting Signal Sequence Cleavage Sites", Nucleic Acids Res. 14:4683-4690.
Wetterau et al., 1990, "Protein Disulfide Isomerase is a Component of the Microsomal Triglyceride Transfer Protein Complex", J. Biol. Chem. 265:9800-9807.
Auffray et al (1995) C.R. Acad Sci III, Sci. Vie 318:263-272 "Image:molecular integration of the analysis of the human genome . . . ", Genbank Seg. F10703.
Hillier et al (1995) "The Washu-Merck EST Project", Genbank T76935.
Annunen Pia Pauliina
Helaakoski Tarja Inkeri
Kivirikko Kari I
Nissi Ritva Kaarina
Nokelainen Minna Kristiina
Academy of Finland
Fibrogen Inc.
Prouty Rebecca E.
LandOfFree
.alpha.2 subunit of prolyl-4-hydroxylase, nucleic acid sequences does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .alpha.2 subunit of prolyl-4-hydroxylase, nucleic acid sequences, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.2 subunit of prolyl-4-hydroxylase, nucleic acid sequences will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-877790