Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2005-09-22
2009-08-11
Benzion, Gary (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120
Reexamination Certificate
active
07572603
ABSTRACT:
The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha-2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment of diseases such as cardiovascular and central nervous system disease.
REFERENCES:
patent: 5595880 (1997-01-01), Weinshank et al.
patent: 5648482 (1997-07-01), Meyer
patent: 5846710 (1998-12-01), Bajaj
patent: 5856092 (1999-01-01), Dale
patent: 5888819 (1999-03-01), Goelet
patent: 5981174 (1999-11-01), Wolf
patent: 6004744 (1999-12-01), Goelet
patent: 6013431 (2000-01-01), Soderlund
patent: 6156503 (2000-12-01), Drazen
patent: 6821724 (2004-11-01), Mittman et al.
patent: 0 874 048 (1998-10-01), None
patent: 06121686 (1994-05-01), None
patent: WO 95/33048 (1995-12-01), None
patent: PCT/US98/21227 (1998-10-01), None
patent: PCT/US99/27963 (1999-11-01), None
patent: WO 00/20450 (2000-04-01), None
patent: WO 01/29082 (2001-04-01), None
Baldwin et al. American Journal of Hypertension, vol. 12, pp. 853-857, Sep. 1999.
Saulnier-Blache et al., Molecular Pharmacology, vol. 50, pp. 1432-1442, pp. 1432-1442, 1996.
Ruffolo, R.R., Jr., Nichols, A.J., Stadel, J.M., and Hieble, J.P. (1993) Annu Rev Pharmacol Toxicol 32, 243-279.
Sallinen, J., Link, R.E., Haapalinna, A., Viitamaa, T., Kulatunga, M., Kobilka, B.K., Macdonald, E., Pelto-Huikko, M., Leino, T., Barsh, G.S., and Scheinin, M. (1997) Mol.Pharmacol. 51, 36-46.
Sallinen, J., Haapalinna, A., Viitamaa, T., Kobika, B.K., and Scheinin, M. (1998) The Journal of Neuroscience 18, 3035-3042.
Tanila, H., Mustonen, K., Sallinen, J., Scheinin, M., and Riekkinen, P., Jr. (1999) European Journal of Neuroscience 11, 599-603.
Bjorklund, M., Sirvio, J., Puolivali, J., Sallinen, J., Jakala, P., Scheinin, M., Kobilka, B.K., and Riekkinen, P., Jr. (1998) Mol Pharmacol 54, 569-576.
Kobilka, B.K., Matsui, H., kobilka, T.S., Yang-Feng, T.L., Francke, U., Caron, M.G., Lefkowitz, R.J., and Regan, J.W. (1987) Science 238, 650-656.
Lomasney, J.W., Lorenz, W., Allen, L.F., King, K., Regan, J.W., Yang-Geng, T.L., Caron, M.G., and Lefkowitz, R.J. (1990) Proc.Nat.Acad.Sci 87, 5094-5098.
Regan, J.W., Kobilka, T.S., Yang-Feng, T.L., Caron, M.G., Lefkowitz, R.J., and Kobilka, B.K. (1988) Proc.Natl.Acad.Sci., USA 85, 6301-6305.
Hein, L., Altman, J.D., and Kobilka, B.K. (1999) Nature 402, 181-184.
Gavin, K.T., Colgan, M.P., Moore, D., Shanik, G., and Docherty, J.R. (1997) Naunyn Schmiedeberg's Arch Pharmacol 355, 406-411.
Sallinen, J., Haapalinna, A., Macdonald, E., Viitamaa, T., Lahdesmaki, J., Rybnikova, E., Pelto-Huikko, M., Kobilka, B.K., and Scheinin, M., (1999) Mol Psychiatry 4, 443-452.
Green, S.A., Cole, G., Jacinto, M., Innis, M., and Liggett, S.B. (1993) J Biol Chem 268, 23116-23121.
Green, S.A., Turki, J., Innis, M., and Liggett, S.B. (1994) Biochem 33, 9414-9419.
Mason, D.A., Moore, J.D., Green, S.A., and Liggett, S.B. (1999) J Biol Chem 274, 12670-12674.
Eason, M.G. and Liggett, S.B. (1992) J. Biol. Chem. 267, 25473-25479.
Fraser, C.M., Arakawa, S., McCombie, W.R., and Venter, J.C. (1989) J. Biol.Chem 264, 11754-11761.
Eason, M.G., Kurose, H., Holt, B.D., Raymond, J.R., and Liggett, S.B. (1992) J.Biol.Chem. 267, 15795-15801.
Jewell-Motz, E.A., Donnelly, E.T., Eason, M.G., and Liggett, S.B. (1998) Biochem 37, 15720-15725.
Schwinn, D.A., Page, S.O., Middleton, J.P., Lorenz, W., Liggett, S.B., Yamamoto, K., Caron, M.G., Lefkowitz, R.J., and Cotecchia, S. (1991) Mol.Pharmacol. 40, 619-626.
Martin, T.F.J. (1983) J Biol Chem 258, 14816-14822.
Eason, M.G., Jacinto, M.T., Theiss, C.T., and Liggett, S.B. (1994) Proc.Natl.Acad.Sci., USA 91, 11178-11182.
Smith, P.K., Krohn, R.I., Hermanson, G.T., Mallia, A.K., Gartner, F.H., Provenzano, M.D., Fujimoto, E.K., Goeke, N.M., Olson, B.J., and Klenk, D.C. (1985) Anal.Biochem. 150, 76-85.
Okamoto, T. and Nishimoto, I. (1992) J.Biol.Chem. 267, 8342-8346.
Ikezu, T., Okamoto, T., Ogata, E., and Nishimoto, I. (1992) FEBS 311, 29-32.
Dorn, G.W., Oswald, K.J., McCluskey, T.S., Kuhel, D.G., and Liggett, S.B. (1997) Biochem 36, 6415-6423.
Luttrell, L.M., van Biesen, T., Hawes, B.E., Koch, W.J., Krueger, K.M., Touhara, K., and Lefkowitz, R.J. (1997) Adv Second Messenger Phosphoprotein Res 31, 263-277.
Schramm, N.L. and Limbird, L.E. (1999) J Biol Chem 274, 24935-24940.
Rosin, D.L., Talley, E.M., Lee, A., Stornetta, R.L., Gaylinn, B.D., Guyenet, P.G., and Lynch, K.R. (1996) J Comp Neurol 372, 135-165.
Shi, T.J., Winzer-Serhan, U., Leslie, F., and Hokfelt, T. (1999) NeuroReport 10, 2835-2839.
Morgan, C.A., Southwick, S.M., Grillon, C., Davis, M., Krystal, J.H., and Charney, D.S. (1993) Psychopharmacology 110, 342-346.
Eason, M.G. and Liggett, S.B. (1993) Mol.Pharmacol.44, 70-75.
Adolfsson, P.I., Dahle, L.O., Berg, G., and Svensson, S.P.S. (1998)Gynecol Obstet Invest 45, 145-150.
Tan, S., Hall, I.P., Dewar, J., Dow, E., and Lipworth, B. (1997) Lancet 350, 995-999.
Liggett, S.B., Wagoner, L.E., Craft, L.L., Hornung, R.W., Hoit, B.D., McIntosh, T.C., and Walsh, R.A. (1998) J Clin Invest 102, 1534-1539.
Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F., Eriksson, P., Lannfelt, L., and Arner, P. (1997) J Clin Invest 100, 3005-3013.
Comings, D.E., Gade-Andavolu, R., Gonzalez, N., Blake, H., Wu, S., and MacMurray, J.P. (1999) Clin Genet 55, 160-172.
Martin Blum, Anne Demierre, Dems M. Grant, Markus Heim, and Urs A. Meyer, Proc.Natl.Acad.Sci.USA, 88:5237-5241 (1991).
Louis M. Luttrell, Tim van Biesen, Brian E. Hawes, Walter J. Koch, Kathleen M. Krueger, Kazushige Touhara, and Robert J. Lefkowitz, Advances in Second Messenger and Phosphoprotein Research, 31:263-277 (1997).
http://www.adrenoceptor.com/alphaintro.htm (printout);visit Apr. 2, 2001.
Small et al. Polymorphic Deletion of Three Intracellular Acidic Residues of the 2B-Adrenergic Receptor decreases G Protein-coupled Receptor K. Nase-Mediated Phosphorylation and Desensitization. The Journal of Biol. Chem. 276:4917-4922 (2001).
Kumari, F., Cotter, P., Corr, P.J., and Gray, J.A. (1996) Psychopharmacology 123, 353-360.
Jinong Feng, Janet L. Sobell, Leonard L. Heston, David Goldman, Edwin Cook Jr., Henry R. Kranzler, Joel Gelernter, and Steve S. Sommer Am. J. Med. Genet. 81:405-410(1998).
Heinonen P. et al: “Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.”The Journal of Clinical Endocrinology and Metabolism, United States, Jul. 1999, vol. 84, No. 7, pp. 2429-2433.
Baldwin C.T., et al: “Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension.”American Journal of Hypertension: Journal of the American Society of Hypertension, United States, Sep. 1999, vol. 12, No. 9, Pt. 1, pp. 853-857.
Jewell-Motz, E.A. et al: “An acidic motif within the third intracellular loop of the alpha2C2 adrenergic receptor is required for agonist-promoted phosphorylation and desensitization.”Biochemistry, United States Sep. 19, 1995, vol. 34, No. 37, Sep. 19, 1995, pp. 11946-11953.
Comings, D.E., et al: “Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects.”Clinical Genetics, Denmark, Mar. 1999, vol. 55, No. 3, pp. 160-172.
Makaritsis K.P., et al: “Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.”Hypertension. United States, Jan. 1999, vol. 33, No. 1, Jan. 1999, pp. 14-17.
Michel M.C., et al: “Functional correlates of alpha(2A)-adrenoceptor gene polymorphism in the HANE study.”Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association-European Renal Association. England, Nov. 1999, vol. 14, No. 11, pp. 2657-2663.
Freeman K., et al: “Gen
Liggett Stephen B.
Small Kersten M.
Benzion Gary
Fenwick & West LLP
University of Cincinnati
Wilder Cynthia B
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