Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-09-19
1998-05-05
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 514260, 544116, 544291, A61K 31535, A01N 4360, C07D41500, C07D23972
Patent
active
057474907
ABSTRACT:
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha 1b adrenergic receptor antagonists. These compounds display submicromolar affinity for the human alpha 1b adrenergic receptor subtype while displaying at least five-fold lower affinity for the human alpha 1d and alpha 1a adrenergic receptor subtypes, and many other G-protein coupled human receptors. One application of these compounds is in the treatment of hypertension. More specifically, these compounds display selectivity for lowering blood pressure without, for example, substantially affecting urethral pressure.
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Bock Mark G.
Lumma William C.
Patane Michael A.
Appollina Mary A.
Merck & Co. , Inc.
Ngo Tamthom T.
Shah Mukund J.
Winokur Melvin
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