Alpha 1-antitrypsin preparation as well as a method for...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C435S219000, C435S236000

Reexamination Certificate

active

06974792

ABSTRACT:
A native, chromatographically purified α1-AT preparation having a purity of at least 0.7 PU/mg protein and a relative plasma α1-AT activity of at least 120% is disclosed. The ratio of active to inactive α1-AT is higher than in plasma.Furthermore, a method of producing this preparation is disclosed, as well as the use of a carrier material, e.g. an inorganic carrier material such as hydroxylapatite for separating active α1-AT from inactive α1-AT.

REFERENCES:
patent: 5610285 (1997-03-01), Lebing et al.
patent: 5760179 (1998-06-01), Fitchmun
Product Information for CHT Cermain Hydroxyapatitle and Bio-gel Hydroxyapatite from the website: http://bio-rad.com/B2B/BioRad/product/br—categoy.
Chan et al. “Purification and Chemical Composition of Human alpha 1-Antitrypsin of the MM Type” FEBS Lett. (1973) 35(1): 79-82.

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