Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-01-15
1994-11-22
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
530350, 530397, 930250, C07H 2104, C07K 1300, C12N 1522
Patent
active
053670647
ABSTRACT:
The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.
REFERENCES:
patent: 4732973 (1988-03-01), Barr et al.
patent: 5079336 (1992-01-01), Rubin
Studier, et al., "Use of Bacteriophage T7 RNA Polymerase to Direct Selective High-level Expression of Cloned Genes," J. Mol. Biol. 189:113-130 (1986).
Tsuda, et al., "Purification Properties and Identification of a Serum DNA Binding Protein (64DP) and Its Microheterogeneity," Tokai J. Exp. Clin. Med. 7:201-211 (1982).
Hill, et al., "Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions," Nature 311:175-177 (1984).
Young, et al., "Efficient isolation of genes by using antibody probes," Proc. Natl. Acad. Sci., USA 80:1194-1198 (1983).
Chandra, et al., "Sequence Homology Between Human .alpha.1-Antichymotrypsin, .alpha.1-Antitrypsin, and Antithrombin III,"Biochemistry 22:5055-5060 (1983).
DelMar, et al., "A Sensitive New Substrate For Chymotrypsin," Anal. Biochem. 99:316-320 (1979).
Ardelt, et al., "Turkey Ovomucoid Third Domain Inhibits Eight Different Serine Proteinases of Varied Specificity on the Same . . . Leu.sup.18 -Glu.sup.19 . . . Reactive Site," Biochemistry 24:5313-5320. (1985).
Laemmli, U. K. "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4," Nature (London) 227:680-685 (1970).
Beatty, et al., "Kinetics of Association of Serine Proteinases with Native and Oxidized .alpha.-1-Proteinase Inhibitor and .alpha.-1-Antichymotrypsin," J. Biol. Chem. 225:3931-3934 (1980).
Towbin, et al., "Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications," Proc. Nat'l Acad. Sci USA 76:4350-4354 (1979).
Carrell and Owen, "Plakalbumin, .alpha..sub.1 -antitrypsin, anithrombin and the mechanism of inflammatory thrombosis," Nature 317:730-732 (1985).
Wachter, et al., "Cloning A Serine Protease Inhibitor Gene With An Antibody Specific Probe", Abstract, Jan. 1987, American Academy of Allergy and Immunology.
Wachter, et al., "Cloning And Antigenic Determinants Of Serine Protease Inhibitors", Abstract, Jan. 1987, Annals of Allergy.
Maniatis, et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 249-255 (1982).
Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 1.74-1.84 (1989).
Morii and Travis, "Amino Acid Sequence at the Reactive Site of Human .alpha..sub.1 -Antichymotrypsin," J. Biol. Chem. 258:12749-12752 (1983).
Cooperman Barry S.
Rubin Harvey
Schechter Norman
Wang Zhi M.
Jacobson Dian C.
The Trustees of the University of Pennylsvania
Wax Robert A.
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