.alpha.-1-antichymotrypsin, analogues and methods of production

Details .alpha.-1-antichymotrypsin, analogues and methods of production .alpha.-1-antichymotrypsin, analogues and methods of production

1991-07-24

1993-10-12

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 692, 4351721, 4351723, 435213, 4353201, C07H 2100, C07K 300, C12N 1509, A61K 4505

Patent

active

052527255

ABSTRACT:
The invention provides .alpha.-1-antichymotrypsin and protein preparations comprising human .alpha.-1-antichymotrypsin produced by E. coli cells transformed with a DNA sequence encoding human .alpha.-1-antichymotrypsin. The invention also provides methods for producing .alpha.-1-antichymotrypsin. The invention further provides analogues of .alpha.-1-antichymotrypsin that exhibit antichymotrypsin, anti-trypsin and anti-thrombin activity and methods of producing the analogues.

REFERENCES:
patent: 4732973 (1988-03-01), Barr et al.
Chandra, T. et al. "Sequence Homology between Human .alpha.1-Antichymotrypsin, .alpha.1-Antrypsin, & Antithrombin III," Biochemistry 22(22):5055-5060 (1983).
Morii, M. et al. "Amino Acid sequence at the Reactive Site of Human .alpha.1-Antichymotrypsin," J. Biol. Chem. 258(21):12749-12752 (1983).
Studier, et al., J. Mol. Biol. 89:113-130 (1986).
Tsuda, et al., Takai, J. Exp. Clin. Med. 7:201-211 (1982).
Young, et al., Proc. Natl. Acad. Sci., USA 80:1194-1198 (1983).
Hill, et al., Nature 311:175-177 (1984).
DelMar, et al., Anal. Biochem. 99:316-320 (1979).
Ardelt, et al., Biochemistry 24:5313-5320.
Laemmli, Nature (London) 227:680-685 (1970).
Beatty, et al., J. Biol. Chem. 225:3931-3934 (1980).
Towbin, et al., Proc. Nat'l Acad. Sci USA 76:4350-4354 (1979).
Carrell and Owen, Nature 317:730-732 (1985).
Wachter, et al., "Cloning A Serine Protease Inhibitor Gene With An Antibody Specific Probe", Abstract, Jan. 1987, American Academy of Allergy and Immunology.
Wachter, et al., "Cloning and Antigenic Determinants of Serine Protease Inhibitors", Abstract, Jan. 1987, Annals of Allergy.
Baumann, et al., J. Mol. Biol. 218:595-606 (1991).

Affiliated with

Also associated with

Rating

.alpha.-1-antichymotrypsin, analogues and methods of production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with .alpha.-1-antichymotrypsin, analogues and methods of production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-1-antichymotrypsin, analogues and methods of production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1905866