Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1990-04-20
1997-07-15
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
800DIG1, 935 60, C12N 500, C12N 1500
Patent
active
056485972
ABSTRACT:
The mice of this invention heritably carry alpha-1-acid glycoprotein (AGP) genes which may be introduced by the transgenic methodology. These animal models are useful for various purposes including 1) assessment of the in vivo role of AGP in the clearance of individual drugs; 2) assessment of the influence of AGP on the pharmacological activity of individual drugs; 3) testing of hypotheses concerning the function of AGP; and 4) identification of the AGP gene cis-acting regulatory features.
REFERENCES:
Cooper et al., Nucleotide Sequence of the Mouse .alpha..sub.1 -Acid Glycoprotein Gene 1, Biochemistry (1987) vol. 26 pp. 5244-5250.
Dente et al., Expression of human .alpha.1-acid glycoprotein genes in cultured cells and transgenic mice, J. Biological Chemistry, (1985) vol. 260, No. 7, pp. 259-266.
Reinke et al., Rat .alpha..sub.1 -Acid Glycoprotein, J. Biological Chemistry, (1985) vol. 260 No. 7., pp. 4397-4403.
Ricca et al., Nucleotide Sequence of Rat .alpha..sub.1 -Acid Glycoprotein Messenger RNA J. Biological Chemistry, vol. 256, No. 21, pp. 11199-11202.
Tomei et al., Use of transgenic mice for the characterization of human alpha 1-acid glycoprotein (orosomucoid) variants, Hum. Genet. (1989) 84:89-91.
Dente, L. et al. (1988) "Expression of Human .alpha.1-Acid Glycoprotein Genes in Cultured Cells & in Transgenic Mice". Genes & Development 2:259-266.
Van Brunt, J. (1988) "Molecular Farming: Transgenic Animals as Bioreactors" Biotechnology 6:1149-1154.
Baumann Heinz
Dewey Michael J.
Crouch Deborah
Health Research , Inc.
University of South Carolina
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