.alpha.(1,3) galactosyltransferase negative porcine cells

Details .alpha.(1,3) galactosyltransferase negative porcine cells .alpha.(1,3) galactosyltransferase negative porcine cells

1996-03-26

2000-11-28

Crouch, Deborah

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 424 9321, C12N 500, C12N 1500, A61K 4800

Patent

active

061534285

ABSTRACT:
Transgenic swine in which the normal expression of .alpha.(1,3) galactosyltransferase is prevented in at least one organ of tissue type. The absence or inactivation of this enzyme prevents the production of carbohydrate moieties having the distinctive terminal Gal.alpha.1-3Gal.beta.1-4GlcNAc epitope that is a significant factor in xenogeneic, particularly human, transplant rejection of swine grafts.

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