Allylmercaptocaptopril compounds and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S953000, C546S245000, C540S607000

Reexamination Certificate

active

10478396

ABSTRACT:
Compounds which are the reaction product of allicin and ACE-inhibiting compounds are useful in treating hypertension, elevated triglycerides, and elevated insulin.

REFERENCES:
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4347371 (1982-08-01), Iwao et al.
patent: WO-97/39115 (1997-10-01), None
Elkayam et al, “The Effects of Allicin and Enalapril in Fructose-Induced Hyperinsulinemic Hyperlipidemic Hypertensive Rats”,Am J Hypertens14:377-381 (2001).
Abramovitz et al “Allicin-induced decrease in formation of fatty steaks (atherosclerosis) in mice fed on a cholesterol-rich diet”, Coronary Artery Disease 10 (1999) pp. 515-519.
Aquel et al “Direct relaxant effects of garlic juice on smooth and cardiac muscles” J Ethnopharmoco1 33(1-2) (1991) pp. 13-19.
Auer et al “Hypertension and hyperlipidaemia: garlic helps in mild cases” Br J clin Pract Suppl 69 (1990) pp. 3-6.
Augusti et al “Lipid towering effect of allicin (diallyldisulphide-oxide on long tern feeding to normal rats” Experientia 30 (1979) pp. 369-373.
Banerjee A “Effect of aqueous extract of garlic on arterial blood pressure of normotensive and hypertensive rats” Artery 2 (1979) pp. 369-373.
Carmel et al “A flourimetric assay for angiotensin-I converting enzyme in human serum” Clinica Chimica Acta 93 (1979) pp. 215-220.
Cushman et al “History of the design of captopril and related inhibitors of angiotensin converting enzyme” Hypertension 17 (1991) pp. 589-592.
Eliat et al “Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic” Coronary Artery Dis 6 (1995) pp. 985-990.
Ehrlich et al “Contribution of nitric oxide to the beneficial effects of enalapril in the fructose-induced hyperinsulinemic rat” Hypertension 28 (1996) pp. 754-757.
Ehrlich et al “Efffect of angiotensin-converting enzyme inhibitors of fructose induced hypertension and hyperinsulinaemia in rats” Clin Exp Pharmocol Physiol 22 (Sup1) (1996) pp. s347-s349.
Foushee et al., “Garlic as a natural agent for the treatment of hypertension: a preliminary” Cytobios 34 (135-36) (1982) pp. 145-152.
Lawson LD in Phytomedicines of Europe: Their Chemistry and Biological Activity (Lawson et al eds.) vol. 691, pp. 176-209, American Chemical Society, Washington (1998).
Malik et al “Hypotensive effect of freeze-dried garlic (Allium sativum) sap in dog” PMA J pak Med Assoc 31 (1981) pp. 12-13.
Materson et al “Angiotensin-converting enzyme inhibitors in hypertension. A dozen years of experience” Arch Intern Med 1544 (1994) pp. 513-523.
Migdalof et al “Captopril: pharmacology, metabolism and disposition” Drug Metab Rev 15 (1984) pp. 841-869.
Miron et al “The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity” Biochim Biophys Acta 1463 (2000) pp. 20-30.
Ondetti et al., “Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents” Science 196 (1977) pp. 441-444.
Petkov U “Plants with hypotensive, antiatheromatous and coronarodilating action” Am J of Chinese Medicine 7 (1979) pp. 197-236.
Rabinkov et al “The mode of action of allicin: trapping radicals and interaction with thiol containing proteins” Biochim Biophys Acta 1379 (1998) pp. 233-244.
Reaven et al “Sugar-induced hypertension in Sprague-Dawley rats” Am J Hypertens 4 (7 Pt 1) (1991) pp. 610-614.
Ruffin et al “An evaluation of the side effects of garlic as an antihypertensive agent” Cytobios 37 (146) (1983) pp. 85-89.
Thind GS “Angiotensin converting enzyme inhibitors: comparative structure, pharmacokinetics, and pharmacodynamics” Cardiovase Drugs Ther 4 (1990) pp. 199-206.

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