Allosteric modulators of the NMDA receptor and their use in the

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence

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514 13, 514 17, 530330, A61K 3808, A61K 3810, C07K 706, C07K 708

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058309985

ABSTRACT:
Novel compounds and compositions for modulating NMDA receptor function comprising Conantokin-G and derivatives thereof; methods for modulating NMDA receptor function and methods for treating neuropsychopharmacological disorders, using the novel compounds and compositions of the invention; and a method for screening compounds capable of binding to a novel allosteric modulatory site are described.

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