Allosteric modifiers of hemoglobin

Details Allosteric modifiers of hemoglobin Allosteric modifiers of hemoglobin

1997-05-08

1999-07-27

Nazario-Gonzalez, Porfirio

Surgery

Miscellaneous

Methods

514421, 514486, 514512, 514513, 514533, 514535, 514538, 514833, 548403, 548416, 548478, 562452, 562425, 562455, A61B 1900, A61K 3140, C07D20948

Patent

active

059272830

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The effect has particular application in a wide variety of treatments including hypoxia, hypothermia, ischemia, stroke, ARDS, COPD, surgical blood loss, acute nonvolemic hemodilutions, wounds, diabetic ulcers, chronic leg ulcers, pressure sores, tissue transplants, and sepsis. The compounds are capable of acting on hemoglobin in whole blood.

REFERENCES:
patent: 5049695 (1991-09-01), Abraham et al.
patent: 5122539 (1992-06-01), Abraham et al.
patent: 5290803 (1994-03-01), Abraham et al.
patent: 5432191 (1995-07-01), Abraham et al.
patent: 5677330 (1997-10-01), Abraham et al.
patent: 5731454 (1998-03-01), Abraham et al.

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