Allosteric hemoglobin modifiers which decrease oxygen affinity i

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548403, 548416, 548473, 560 30, 560 31, 560 32, C07D20948, C07D20900, C09B 500, A61K 3140

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active

052507017

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.

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patent: 3218334 (1965-11-01), Smith et al.
patent: 3960874 (1976-06-01), Carney
patent: 4737512 (1988-04-01), Hoefle

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