Allosteric hemoglobin modifiers useful for decreasing oxygen aff

Details Allosteric hemoglobin modifiers useful for decreasing oxygen aff Allosteric hemoglobin modifiers useful for decreasing oxygen aff

1991-05-20

1992-06-16

Gray, Bruce

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514488, 514490, 514512, 514513, 514533, 514535, 514538, 514833, 514486, 560 30, 560 31, 560 32, 568452, 568455, A61K 31245, A61K 31195, A61K 31325, C07C 4500

Patent

active

051225395

ABSTRACT:
Compounds of the general structural formula: ##STR1## wherein X, Y and Z may each be CH.sub.2, NH, or O, R.sub.2-6 are either hydrogen, halogen, or a substituted or unsubstituted C.sub.1, C.sub.2, or C.sub.3 alkyl group and these moieties maybe the same or different, or alkyl moieties of aliphatic or aromatic rings incorporating two of the R.sub.2-6 sites, R.sub.7-8 are hydrogen, methyl, or ethyl groups and these moieties may be the same or different, or alkyl moieties as part of an aliphatic ring connecting R.sub.7 and R.sub.8, and R.sub.9 is a hydrogen, loweralkyl such as methyl, ethyl or propyl, or a salt cation such as sodium, potassium, or ammonium are useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.

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patent: 4699926 (1987-10-01), Abraham et al.
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patent: 4887995 (1989-12-01), Abraham et al.
M. F. Perutz, "Mechanisms of Cooperativity and Allosteric Regulation in Proteins", Quarterly Reviews of Biophysics 22, 2 (1980), pp. 163-164.
Lalezari et al., "LR16, a Compound With Potent Effects on the Oxygen Affinity of Hemoglobin, on Blood Cholesterol, and on Low Density Lipoprotein", Proc. Natl. Acad. Sci., USA 85 (1988), pp. 6117-6121.

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